今日更新:Journal of the Mechanics and Physics of Solids 1 篇,International Journal of Plasticity 1 篇,Thin-Walled Structures 2 篇
A multiscale mechanobiological model of physiological and pathological cardiac hypertrophy
Shihao Xu, Xindong Chen, Xiangjun Peng, Bo Li, Xi-Qiao Feng
doi:10.1016/j.jmps.2025.106349
生理和病理心肌肥大的多尺度力学生物学模型
Cardiac hypertrophy involves dynamic heart remodeling associated with mechanical and biochemical stimuli, while physiological and pathological cardiac hypertrophy can lead to distinct clinical outcomes. However, most previous models fail to distinguish these types, or properly account for cytoskeletal-extracellular matrix (ECM) remodeling effects. In this study, we develop a multiscale mechanobiological model by coupling cardiac mechanical behaviors with cardiomyocyte growth through mechanosensitive signaling pathways. This model considers tissue microstructures to characterize how cytoskeletal-ECM remodeling alters the mechanical forces sensed by cardiomyocytes. Our model can well predict experimental measurements of ventricular wall thickness and signaling activation in both physiological and pathological hypertrophy, enabling their clear differentiation. We demonstrate that exercise-induced hypertrophy attenuates pathological remodeling by alleviating myocardial mechanical stress to suppress mechanotransduction. We also elucidate the synergistic or antagonistic interaction mechanis ms among factors such as hypertension, exercise, cardiomyocyte death and fibrosis in cardiomyocyte growth and pathological signaling. These results highlight the importance of myocardial microenvironment in cardiac remodeling. Furthermore, computational evaluation demonstrates that muscle LIM protein-targeted therapies have potential for treating pathological hypertrophy through mechanotransduction modulation, but excessive dosing may elevate arrhythmia risks. This study not only advances mechanistic understanding of physiological and pathological cardiac hypertrophy, but also provides a theoretical basis for developing mechanobiology-informed therapeutic techniques.
心肌肥厚涉及与机械和生化刺 激相关的动态心脏重塑,而生理性和病理性心肌肥厚可导致不同的临床结果。然而,大多数先前的模型未能区分这些类型,或正确地解释细胞骨骼-细胞外基质(ECM)重塑效应。在这项研究中,我们通过机械敏感信号通路将心脏力学行为与心肌细胞生长耦合,建立了一个多尺度力学生物学模型。该模型考虑组织微观结构来表征细胞骨骼- ecm重塑如何改变心肌细胞感知的机械力。我们的模型可以很好地预测生理和病理性肥大的心室壁厚度和信号激活的实验测量,使它们能够明确区分。我们证明,运动诱导的肥大通过减轻心肌机械应力抑制机械转导来减轻病理性重塑。我们还阐明了高血压、运动、心肌细胞死亡和纤维化等因素在心肌细胞生长和病理信号传导中的协同或拮抗相互作用机制。这些结果强调了心肌微环境在心脏重构中的重要性。此外,计算评估表明,肌肉LIM蛋白靶向治疗有可能通过机械转导调节来治疗病理性肥大,但过量可能会增加心律失常的风险。这项研究不仅促进了对生理和病理心肌肥厚的机制认识,而且为开发基于机制生物学的治疗技术提供了理论基础。
Novel approach to achieve gigapascal level yield strength and large uniform elongation in metastable β-Ti alloys
Xiu-Qun Wang, Yan Chong, Masatoshi Mitsuhara, Nobuhiro Tsuji
doi:10.1016/j.ijplas.2025.104466
实现亚稳β-钛合金千兆帕级屈服强度和大均匀伸长率的新方法
Metastable β titanium alloys exhibit an excellent strain hardening ability and a large uniform elongation, but their widespread use is challenged by a relatively low yield strength. The low yield strength of metastable β titanium alloys is partly due to an early initiation of strain-induced β-to-α″ phase transformation. Here, we propose a novel and cost-effective approach to solve this problem in a model Ti-10wt.% Mo alloy by refining the grain size and adding oxygen solute. An unprecedented high yield strength of 1040 MPa and a large uniform elongation of 20% are realized in a fine-grained (average grain size: 5 µm) Ti-10wt.% Mo-0.5wt.% O alloy. The superior strength-ductility balance is attributed to a ‘delayed and partially suppressed’ β-to-α″ phase transformation, due to the combined effects of fine grain size and oxygen solute. The delayed β-to-α″ phase transformation (until a plastic strain of 2.1%) endows dislocation slips as the main factor determining the yield strength, thus enabling a full harness of grain boundary strengthening and oxygen solute hardening. Moreover, {332} twinning activated at the early stage and strain-induced α″ martensite initiated at the later stage of deformation provide continuous strain-hardening capabilities up to a relatively larger strain. Finally, the formation of relatively soft α″ martensite helps to relax the stress localization at slip bands, delaying the formation of microcracks, compared to the coarse-grained counterparts. The novel approach in the present study provides a general strategy to manage both high yield strength and large uniform elongation in metastable β titanium alloys, via tailoring both structural (grain size) and compositional (oxygen content) parameters of the material.
亚稳态β钛合金具有优异的应变硬化能力和较大的均匀伸长率,但屈服强度较低,阻碍了其广泛应用。亚稳β钛合金屈服强度低的部分原因是由于应变诱导β-to-α″相变的早期发生。在此,我们提出了一种新颖且具有成本效益的方法来解决模型Ti-10wt中的这一问题。通过细化晶粒尺寸和添加氧溶质来制备% Mo合金。在细晶(平均晶粒尺寸:5µm) Ti-10wt中实现了前所未有的1040 MPa的高屈服强度和20%的大均匀伸长率。% mo - 0.5 wt。% O合金。优异的强度-塑性平衡是由于细晶粒尺寸和氧溶质的共同作用导致β -α″相变的“延迟和部分抑制”。延迟的β -α″相变(直到塑性应变为2.1%)使位错滑移成为决定屈服强度的主要因素,从而使晶界强化和氧溶质硬化得以充分发挥。此外,{332}孪晶在变形早期激活,应变诱导α″马氏体在变形后期启动,提供了持续应变硬化能力,直至相对较大的应变。与粗晶相比较,相对柔软的α″马氏体的形成有助于松弛滑移带的应力局部化,延缓微裂纹的形成。本研究中的新方法提供了一种通过调整材料的结构(晶粒尺寸)和成分(氧含量)参数来管理亚稳β钛合金的高屈服强度和大均匀伸长率的通用策略。
A novel approach for Mindlin plate theory and application to exact solution of free vibration of moderately thick rectangular plates with two opposite guided sides
Fei Long, Ya-Wei Wang, Xian-Fang Li
doi:10.1016/j.tws.2025.113866
用Mindlin板理论精确求解中厚双导边矩形板自由振动的新方法
This study has two aims. One is to provide a novel approach for deriving the governing equation of the Reissner–Mindlin plate theory or Mindlin plate theory (MPT) and the other is to obatin exact solutions for the free vibration of thickness-torsion-locking moderately thick rectangular plates with two opposite guided sides. First, the paper introduces a simplified an alytical method to deduce the governing equations that retain the essential features of shear deformation and rotary inertia of the section. By introducing two unknown functions, one satisfies a fourth-order partial differential equation (PDE) which dominates the flexure of plates and the other meets a second-order PDE which dominates the torsion along the thickness direction. For thickness-torsion-locking (TTL) plates, only a single function is required to satisfy a fourth-order PDE and effective shear force is introduced to include the role of the twisting moment. For plates with two opposite sides guided, the free vibration of TTL plates is exactly solved by a Levy-like solution. The exact characteristic equations are determined for ten combinations of the other sides, including clamped, hinged, guided, and free edges. Accurate natural frequency parameters and the corresponding mode shapes are given. The effects of aspect ratio, thickness-to-side-length ratio, and boundary conditions on the vibration characteristics of plates are discussed in detail. The exact closed-form characteristic equations and their associated characteristic functions for thin plates with opposite guided supports can be reduced only if the shear stiffness is sufficiently large.
这项研究有两个目的。一是为推导Reissner-Mindlin板理论或Mindlin板理论(MPT)的控制方程提供了一种新的方法;二是获得了厚度-扭转-锁紧的中厚矩形板的自由振动的精确解。首先,本文介绍了一种简化的解析方法来推导控制方程,该方程保留了截面的剪切变形和旋转惯量的基本特征。通过引入两个未知函数,一个满足控制板挠度的四阶偏微分方程,另一个满足控制厚度方向扭转的二阶偏微分方程。对于厚扭锁紧(TTL)板,只需一个函数即可满足四阶偏微分方程,并引入有效剪切力,其中包括扭矩的作用。对于有两个相对边引导的板,TTL板的自由振动用类列维解精确求解。确定了其他边的十种组合的确切特征方程,包括夹紧边、铰接边、导向边和自由边。给出了精确的固有频率参数和相应的模态振型。详细讨论了宽高比、厚边长比和边界条件对板振动特性的影响。只有当剪切刚度足够大时,具有相反导向支承的薄板的精确闭型特征方程及其相关特征函数才能减小。
Formation of twisted hierarchical patterns through sequential film depositions and wrinkles
Senjiang Yu, Boyuan Huang, Dongyu Yang, Qiaofan Wang, Zhixiang Chen, Lingwei Li, Yong Ni
doi:10.1016/j.tws.2025.113926
通过连续的薄膜沉积和褶皱形成扭曲的层次图案
Wrinkle patterns arising from surface instabilities are widespread in natural and engineered systems, with broad potential in electronics, optics, bionics and surface engineering. Although various methods—such as thermal expansion, swelling, mechanical loading, and light irradiation—have been developed to create diverse morphologies, generating complex hierarchical wrinkles with controllable features remains a challenge. Here, we report tunable hierarchical wrinkle patterns in film-substrate systems via multistep film deposition and sequential release of nonorthogonal biaxial prestretch. The first deposition and strain release yield unidirectional stripe wrinkles, while a second deposition followed by strain release along a nonorthogonal direction induces twisted hierarchical morphologies through the interaction of two wrinkle generations. The pattern formation process, morphology, and underlying mechanics are elucidated through experiments, theoretical a nalysis, and finite element simulations. This study elucidates the role of multistep deposition and sequential prestretch release in symmetry-breaking wrinkle formation and offers a simple yet versatile strategy for engineering ordered hierarchical wrinkles for practical applications.
表面不稳定性引起的褶皱图案在自然和工程系统中广泛存在,在电子、光学、仿生学和表面工程中具有广泛的潜力。尽管各种方法(如热膨胀、膨胀、机械载荷和光照射)已经开发出各种形态,但产生具有可控特征的复杂分层皱纹仍然是一个挑战。在这里,我们通过多步骤薄膜沉积和非正交双轴预拉伸的顺序释放,报告了薄膜-衬底系统中可调的分层皱纹模式。第一次沉积和应变释放产生单向条状褶皱,而第二次沉积和应变释放通过两代褶皱的相互作用产生扭曲的层次化形貌。图案的形成过程,形态和潜在的力学是通过实验,理论分析和有限元模拟阐明。本研究阐明了多步骤沉积和顺序预拉伸释放在对称性破皱形成中的作用,并为实际应用中的工程有序分层皱纹提供了一种简单而通用的策略。